Multi-Layer Brain-Mimicking Phantom for Neural Interface Implantation Testing

Summary Researchers developed a reproducible multi-layer brain-mimicking phantom that replicates the dimpling and rupture forces of rodent pia mater and dura mater during neural interface implantation, built from a 0.5% agarose skin layer, a 1.01% agarose pia layer and a pre-stretched PVC dura layer assembled in a simple benchtop process. Tested with a cantilever force system on microwires of 12–100 µm diameter (tungsten and stainless steel, various tip geometries) and segmented silicon probes, the phantom produced results within the range of in vivo Sprague-Dawley rat data with significantly lower insertion variability than in vivo testing. The authors say its modular design — layer thickness and stiffness can be tuned for different species or devices — makes it a low-cost early screening platform that can accelerate neural implant development while reducing animal use.