According to the registration, the SpeechBCI protocol will test two complementary approaches in the same subject: a speech BCI (primary objective, the BCI_PAROLE device) and a cursor BCI (secondary objective), both using the WIMAGINE intracranial epidural system, which aims for limited risk of infection and brain injury and more stable signals over time.
University Hospital, Grenoble Registers Chronic BCI Study for Speech Rehabilitation in Locked-In Syndrome
Summary
Grenoble University Hospital has registered a clinical study (NCT07698496) assessing the feasibility and effectiveness of a chronic brain-computer interface for speech rehabilitation in people with locked-in syndrome (LIS), where non-invasive communication carries high cognitive load and existing invasive speech BCIs still rely on percutaneous connectors with infection risk. Using an intracranial epidural BCI paired with a speech synthesizer, the SpeechBCI protocol will test two complementary approaches in the same subject — a speech BCI (primary objective, the BCI_PAROLE device) and a cursor BCI (secondary), both running on the WIMAGINE intracranial epidural system. The trial is in the registration stage and has no clinical results yet.
Why it matters
The registration matters because it targets a documented gap — a fully implantable, wireless, real-time speech BCI suitable for long-term home use — and its NCT07698496 identifier makes the study trackable as the field shifts from percutaneous, hospital-bound speech implants toward home-deployable systems.
Compiled by BCIwiki from public sources
Sources · 1
clinicaltrials.gov 2026-07-13