The authors benchmark bidirectional wireless links across inductive, mid-field, RF, ultrasonic, magnetoelectric, optical, UWB and electro-quasistatic modalities against the clinical axes of depth, size and data rate. Their central numbers: an approximately 1 degree Celsius tissue-heating ceiling sets a communication budget of roughly 10 mW. Within that budget, narrowband high-Q links are well suited to power transfer and low-speed data, but at 1-10 nJ/b they cannot reach the greater than 10 Mbps to tens of Gbps uplinks that thousand- to million-channel interfaces demand, even with aggressive on-implant compression.
The review concludes that such interfaces call for sub-10 pJ/b and ultimately sub-1 pJ/b wireless links, where wideband techniques such as ultra-wideband and brain-channel communication are suitable. It closes with a quantitative framework for analyzing these links and a co-design roadmap across electromagnetics, circuits, packaging, security and regulation, toward secure, networked, million-channel brain interfaces.