For a C5 tetraplegic participant, the study integrated anatomical, functional and vascular imaging with preoperative 3D modeling to optimize placement of intracortical microelectrode arrays for grasp-related motor decoding. Anatomical MRI, diffusion-weighted imaging and task-based fMRI identified grasp-related cortex while avoiding vasculature and speech-critical regions; Quicktome software refined target selection using structural connectivity and functional activation data, and 3D-printed skull and cortex models supported surgical planning. Functional imaging highlighted the anterior intraparietal sulcus (AIP), ventral premotor cortex (PMv) and inferior frontal gyrus (IFG); arrays placed in AIP and PMv subregions 6v and 6r reached a combined classification accuracy of 96%.
