Yonsei University Collaboration Tracks Partial Cortical Network Recovery Without Return to the Pre-Stroke State in Mice
A collaboration involving Yonsei University used a fully soft, liquid metal-based multichannel neural interface to record stable electrophysiological signals in freely moving mice and compare cortical networks within the same animals before and after ischemic stroke. Analyses of population-level activity patterns and functional connectivity both showed acute suppression followed by partial recovery. The peri-infarct networks did not return to their pre-stroke state, instead reorganizing into a distinct, reproducible functional configuration. The study demonstrates an approach to tracking network reorganization during recovery, rather than treating stroke with the interface or establishing rehabilitation benefits in humans.
