Hybrid micro-ECoG for multi-scale neural recording
Published in Cell Reports Methods on June 12, 2026, the study presents high-density micro-electrocorticography arrays that integrate silicone elastomers (optical transparency, repeated penetration with intracortical arrays) and polyimide films (fine photolithographic feature definition) for multi-scale studies of brain activity. The combination facilitates high-throughput functional mapping to identify targets and insertion of intracortical arrays for dense local sampling. The authors demonstrated functional mapping in rats, cats and marmosets, guiding multi-area laminar recordings, and demonstrated local and feedforward optogenetic stimulation to investigate cortico-cortical interactions.