2026-09-03 00:00 Japan Papers Foundations & Methods Translated from EN

Endovascular EEG Records 3.7 Times the Power of Scalp EEG in 5 Patients

Summary Endovascular EEG recorded approximately 3.7 times the power of concurrent scalp EEG in 5 patients undergoing an intracarotid amobarbital injection, known as the Wada test, and the nearest endovascular-scalp electrode pairs showed consistently higher coupling in every participant, a mean difference of 4.9 percentage points ranging from 1.8% to 7.6% across individuals and most pronounced at separations under 30 mm. Endovascular EEG has emerged as a brain monitoring technique that balances signal fidelity against invasiveness, the authors write, matching subdural recordings in bandwidth and signal-to-noise ratio in animal studies, but its signal properties have been sparsely quantified in people. All signals were preprocessed with artifact rejection and independent component analysis, then assessed with power spectral density, imaginary coherence, phase-locking value and amplitude envelope correlation.

Why it matters The case for endovascular electrodes has rested largely on animal work showing they approach subdural quality without a craniotomy, which leaves the human operating range unspecified. Measuring power and scalp coupling directly in patients converts that claim into numbers a device team can design against. The cohort is 5 patients recorded during a Wada test, so the setting is diagnostic rather than a working interface.

BCIwiki (bciwiki.com) – The study was published in IEEE Transactions on Bio-Medical Engineering on September 3, 2026. Researchers evaluated endovascular EEG signals from 5 human participants undergoing intracarotid amobarbital injection, the Wada test, while scalp and endovascular EEG were recorded simultaneously. Endovascular EEG has emerged as a brain monitoring technique offering a balance between signal fidelity and invasiveness, the authors write, and endovascular electrodes match subdural recordings in bandwidth and signal-to-noise ratio in animal studies, though their signal properties remain sparsely quantified in humans.

All signals were preprocessed with artifact rejection and independent component analysis, according to the paper, and power spectral density, imaginary coherence, phase-locking value and amplitude envelope correlation were computed to quantify signal quality and functional connectivity. Endovascular EEG signals exhibited approximately 3.7 times higher power than concurrent scalp EEG, and the nearest endovascular-scalp electrode pairs showed consistently higher coupling across all participants, with a mean difference of 4.9 percentage points and a range of 1.8% to 7.6% across individuals, most pronounced at distances under 30 mm.

These findings support the feasibility of endovascular EEG for neuromonitoring and demonstrate its potential for simple brain-computer interface applications, the authors say. The work provides quantitative measures of signal power and of correlation with scalp EEG obtained directly in humans for a microcatheter-deliverable wire electrode, establishing human operating bounds for the technique. The evidence package carries no author affiliation data.

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pubmed.ncbi.nlm.nih.gov 2026-09-03

Invasive BCI EEG Endovascular BCI Japan

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