This study, published in Advanced Science (Weinheim, Baden-Württemberg, Germany), presents an integrated ultrasonic platform using a physics-constrained metasurface design framework for high-resolution multifocal ultrasound energy delivery through highly aberrating biological barriers such as the skull and ribs, achieving about 6.5% intensity uniformity across multiple foci.
The platform demonstrates attention-based and cardiac-synchronized adaptive stimulation paradigms and introduces a dual-channel acoustic link enabling continuous wireless power and data streaming through the skull, robust even with a 400-fold power differential, contributing to next-generation ultrasonic brain-machine interfaces (uBMIs) and closed-loop bioelectronic therapies. PMID 42095521, DOI 10.1002/advs.75563