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2024-08-21 00:00 United States Clinical Safety & Termination Translated from EN

Neuralink Details Thread Retraction and Surgical Changes in PRIME Study

入组8 例阶段早期可行性
Summary Neuralink said thread retraction in its first PRIME participant temporarily reduced BCI performance before the threads stabilized and performance recovered. For the second implant, the team reduced brain motion during surgery and narrowed the gap between the implant and the brain surface. The company reported no thread retraction in the second participant at the time, but it did not publish channel-attrition rates or a formal interim safety report.
Why it matters Thread retention is central to whether flexible intracortical electrodes can preserve signal over time, making the disclosed surgical changes more informative than a broad safety claim.
BCIwiki (bciwiki.com) — Neuralink acknowledged on August 21, 2024, that thread retraction in its first PRIME participant had temporarily reduced BCI performance. The company said the threads later stabilized and performance recovered.

For the second implantation, the team took steps to reduce brain motion during surgery and narrow the gap between the implant and the brain surface. Neuralink reported no thread retraction in the second participant at the time of the update. He began controlling a cursor less than five minutes after connecting the system and used computer-aided design software on his second day.

The company update described a specific failure mode and mitigation, but it did not provide long-term survival data for each thread or channel and was not a formal interim safety report. The absence of retraction in the second participant at that point was a short-term observation that requires longer follow-up.

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2026-01 Neuralink Expands Its Global BCI Trial Cohort to 21 Participants All entries →
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