BCIwiki (bciwiki.com) — Hospices Civils de Lyon has registered a clinical study to decode motor imagery from non-invasive brain recordings as a prerequisite for innovative motor rehabilitation therapies. The study was first posted on ClinicalTrials.gov on July 28, 2026, under identifier NCT06469463, covering conditions such as stroke sequelae, motor imagery, and upper limb deficit, with interventions including MRI, MEG, and EEG.
The study notes that standard non-invasive brain-computer interface (BCI) approaches rely on event-related desynchronization (ERD) and event-related synchronization (ERS), which emerge only after averaging over multiple trials, thus neglecting transient features such as beta bursts in single trials. The researchers will use MRI and MEG to design a subject-specific neurophysiological model, employing an individualized head cast (hpMEG) to improve source localization accuracy, and will use this model to constrain online decoding of EEG data. The approach will be validated in healthy adults and compared against a classic EEG-based BCI, then assessed for feasibility in a few stroke patients with upper-limb motor deficits.
The team argues that beta bursts may carry more behaviorally relevant information than averaged beta band power, and that conventional signal processing methods, which assume sustained oscillations, are unsuitable for analyzing transient activity. This is an early feasibility study; specific results have not yet been reported.