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2025-01-02 00:00 China Clinical Results & Follow-up Translated from ZH

NeuroXess Decodes 142 Mandarin Syllables at 71% Accuracy

阶段研究者发起临床研究适应症语言功能
Summary NeuroXess and Huashan Hospital reported a single-patient test of a 256-channel flexible implantable BCI. In postoperative training, decoding accuracy reached 71% across 142 commonly used Mandarin syllables, with per-character latency below 100 milliseconds. The participant had a language-area tumor and epilepsy, so the company-reported result does not establish performance in people who have lost speech.
Why it matters Mandarin syllables and tones pose a different decoding problem from English, making this a useful early data point that still needs replication in more patients and an independent paper.
BCIwiki (bciwiki.com) — NeuroXess and Huashan Hospital, Fudan University, reported a single-patient speech-decoding test with a flexible implantable BCI in early January 2025. The participant was a 43-year-old patient with a language-area tumor and epilepsy, and the team used a 256-channel array during surgery to help localize the lesion and preserve language function.

The company said training began two days after surgery and reached 71% decoding accuracy across 142 commonly used Mandarin syllables, with per-character latency below 100 milliseconds. By day seven, the system covered 418 Mandarin syllables. Decoded signals were also used for speech synthesis, a digital avatar, interaction with a large language model and control of a robotic hand.

The figures come from a company report of one case. The participant could speak, and the implant was used alongside an existing neurosurgical procedure, conditions that differ from late-stage ALS or post-stroke speech loss. The result supports feasibility but needs testing in more nonverbal patients with standardized tasks and peer-reviewed reporting.

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