Trials

The Chinese Clinical Trial Registry (ChiCTR) has logged a study of the safety and efficacy of early brain-computer interface training given after reperfusion therapy in patients with acute ischemic stroke, an attempt to pin down when in the recovery window such training should start. Registered on April 27, 2026 as ChiCTR2600123548, the trial has not begun recruiting, and design, sample size and sponsor are absent from the record carried by the WHO International Clinical Trials Registry Platform (ICTRP) and must be read from the original registration.

The Chinese Clinical Trial Registry (ChiCTR) has logged a multicenter randomized controlled trial testing whether brain-computer interface-based mindfulness meditation relieves the symptoms of chronic tinnitus. Registered on April 23, 2026 as ChiCTR2600123258, the trial has not begun enrolling patients, and its design, sample size and sponsor must be read from the original registration record. It is the first multicenter registration to combine BCI with mindfulness meditation for chronic tinnitus, moving the approach from single-center exploration toward multicenter validation.

A trial registered with the Chinese Clinical Trial Registry combines low-frequency rTMS with motor imagery brain-computer interface therapy, using conventional physical rehabilitation as the control, with the Fugl-Meyer upper extremity scale as the primary endpoint. The study has three parts: Part I compares BCI therapy with conventional rehabilitation, while Part III compares three rTMS protocols. It plans to enroll 213 participants, with first enrolment set for May 1, 2026; recruitment has not yet begun.

The trial combines a brain-computer interface with robotic mirror therapy into a single intervention, while the control arm receives conventional comprehensive rehabilitation only. It enrolls patients aged 30 to 80 with unilateral upper-limb motor impairment 1 to 6 months after ischemic or hemorrhagic stroke, whose lesions are confined to the basal ganglia. The primary endpoint is the Fugl-Meyer Assessment of the Upper Extremity, with EEG, functional MRI and the Modified Ashworth Scale among secondary measures. The planned enrollment is 40 patients, with first enrollment set for May 1, 2026.

A trial of a dual-task brain-computer interface (BCI) combining motor-intention detection with virtual reality training is recruiting patients to measure how it affects shoulder function after rotator cuff repair surgery, following its registration with the Chinese Clinical Trial Registry (ChiCTR) on April 20, 2026. The record has been reposted by the WHO International Clinical Trials Registry Platform (ICTRP).

A brain-computer interface (BCI) trial for upper-limb motor rehabilitation after hemorrhagic stroke was registered with the Chinese Clinical Trial Registry under the number ChiCTR2600122859 on April 20, 2026, and has not yet begun recruiting. The study combines electroencephalography (EEG) with functional near-infrared spectroscopy (fNIRS). The registration record does not disclose the study design, sample size or sponsor.

A trial registered in China pairs brain-computer interface technology with mindfulness meditation training for adolescents with depression, recording EEG alongside the sessions to see how brain activity changes. The question is whether real-time brain signals can be read during meditation and fed back into the training, making the intervention more responsive to each participant's state. Recruitment has not yet started, and the design, sample size and sponsor have not been disclosed.

Johns Hopkins University has launched the INTENT clinical trial to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different brain areas, enabling adults with disabling paralysis to control assistive devices and receive feedback. The trial is now recruiting participants with conditions including tetraplegia, ALS, brain stem stroke, and spinal cord injury. Johns Hopkins is a leading U.S. research university whose medical school is renowned in neuroscience. The trial was first posted on ClinicalTrials.gov on April 13, 2026, and is currently recruiting.

A randomized controlled trial of motor-imagery brain-computer interface (BCI) training for swallowing difficulty after stroke was registered with the Chinese Clinical Trial Registry (ChiCTR) on April 9, 2026, under the number ChiCTR2600122162. It will test whether the training improves swallowing function in stroke patients, and has not yet begun recruiting.

A new entry in the Chinese Clinical Trial Registry covers a study using brain-computer interface technology for functional recovery after stroke. The record, ChiCTR2600120924, was posted on March 23, 2026, and lists its status as not yet recruiting. The registry listing carries only bibliographic details, so the trial design, sample size and sponsor remain undisclosed.

A Chinese trial will measure the immediate effects of a non-invasive brain-machine interface combined with multimodal training on neurophysiological function in patients with upper-limb hemiparesis after stroke. It was registered with the Chinese Clinical Trial Registry as ChiCTR2600120046 on March 9, 2026 and has not begun recruiting.

The Chinese Clinical Trial Registry (ChiCTR) has logged a study of a brain-computer interface (BCI)-enabled cognitive rehabilitation system, set to test its clinical effect in patients with mild cognitive impairment. Registered on February 25, 2026 as ChiCTR2600119334, the trial is not yet recruiting.

Neuracle Medical Technology (Shanghai) Co., Ltd. ran a clinical trial in China evaluating the safety and efficacy of its implantable wireless brain-computer interface, NEO, in patients with tetraplegia caused by spinal cord injury. The trial is registered on ClinicalTrials.gov as NCT06990412 and is listed as completed; its stated primary purpose was to provide the basis for product registration. NEO is designed to let patients control external devices with brain signals.

The University of Miami has opened a clinical trial testing whether a brain-computer interface can decode upper-limb motor intention from EEG or ECoG and use it both to trigger epidural spinal cord stimulation (ESCS) and to control assistive devices in people with spinal cord injury. The study was first posted on August 1, 2024, and is recruiting.

Chinese registry ChiCTR2400081380 describes a 96-patient trial of an implantable closed-loop recording and stimulation system for focal drug-resistant epilepsy in people aged 6 to 70. All participants are to receive the implant and then be randomized one month later to active or sham stimulation, 48 per group. The registry provides no evidence that enrollment had passed 50%.