BCIwiki (bciwiki.com) — The University of Texas at Austin has registered a clinical study on ClinicalTrials.gov to investigate whether an EEG-based brain-computer interface (BCI) decoding the P300 event-related potential in real time, combined with non-invasive interventions such as mindfulness relaxation or transcranial electrical stimulation, can enhance attention and memory neural markers in healthy older adults and those with mild cognitive impairment (MCI). The trial was first posted on July 27, 2026, is currently recruiting, and is planned to take place in the United States.
The study hypothesizes that attention-related neural markers can be selectively enhanced using a BCI combined with non-invasive interventions. Participants will perform a computerized memory task while their EEG signals are recorded in real time. The BCI will decode the presence or absence of the P300, a well-established neural marker of attentional control and cognitive resource allocation, and use real-time feedback and intervention to modulate these neural processes, aiming to promote adaptive changes in attention-related brain activity. The study seeks to determine whether integrating EEG-based decoding, behavioral training, and non-invasive interventions can support cognitive reserve in aging and mild cognitive impairment.