Hemiplegia

Two participants typed Vietnamese at 4.95 and 3.45 characters per minute using motor imagery EEG in a pilot test of BCI-vSpeller, a speller built around a custom virtual keyboard of more than 160 selectable keys covering characters, tone marks and special symbols. Researchers from VNU University of Engineering and Technology in Hanoi, reported the findings in Technology and Disability. BCI spellers let users enter text by controlling an interface with mental signals, an approach aimed at people with severe speech and mobility impairments.

The Chinese Clinical Trial Registry (ChiCTR) has logged a study of how brain-computer interface training built on a motor imagery paradigm affects lower-limb motor function in stroke patients. Registered on May 28, 2026 as ChiCTR2600125562, the trial is recruiting; design, sample size and sponsor are absent from the record carried by the WHO International Clinical Trials Registry Platform (ICTRP) and must be read from the original ChiCTR entry.

The randomized controlled trial plans to enroll 60 patients with lower limb motor impairment after stroke, with the intervention group receiving BCI-assisted exoskeleton rehabilitation training and the control group conventional walking training. Primary outcomes include lower limb surface electromyography, lower limb motor function, the Modified Barthel Index, a balance scale and functional ambulation, testing whether a BCI-driven exoskeleton adds functional benefit over conventional gait training. Punan Hospital, Pudong New Area, Shanghai is the sponsor, with first enrolment set for May 30, 2026. The trial is registered with the Chinese Clinical Trial Registry (ChiCTR) under number ChiCTR2600125531, with a registration date of May 28, 2026, and recruitment has not yet started.

Guangdong Provincial Hospital of Traditional Chinese Medicine has registered a parallel-design interventional trial, ChiCTR2600124411, that plans to enroll 81 patients with unilateral upper-limb impairment after stroke in three groups of 27. Two groups receive intermittent theta-burst stimulation (iTBS) over the dorsolateral prefrontal cortex or the primary motor cortex, and one receives sham stimulation; all three undergo motor imagery BCI training. Primary outcomes are BCI decoding accuracy, the Fugl-Meyer Assessment and brain network topology. The trial was registered on May 12, 2026 and is not yet recruiting.