Movement Disorders

The trial plans to enroll 40 patients with Parkinson's disease aged 40 to 80, randomized into 2 groups: one adds brain-computer interface rehabilitation training to functional electrical stimulation, the other receives functional electrical stimulation alone. Both arms train 20 minutes per day for the upper extremities and 20 minutes per day for the lower extremities, completing 12 treatment days within 2 weeks. The primary endpoint is a motor symptom rating scale, with diffusion tensor imaging, magnetic resonance spectroscopy, resting-state fMRI, and sleep, cognitive and mood scales as secondary endpoints, testing whether adding BCI training produces measurable change beyond motor symptoms.

Researchers assessed the feasibility of a hybrid brain-computer interface that integrates motor imagery (MI) and steady-state visual evoked potentials (SSVEP) with robotic glove feedback for upper limb motor rehabilitation in 32 stroke patients, split into a conventional-treatment control group and an experimental group receiving 10- or 20-day BCI interventions. The experimental group showed considerable improvement in Fugl-Meyer scores over the control group, and the BCI achieved EEG classification accuracy up to 98.08% with stable operation; after longer training, accuracy rose, the laterality coefficient moved toward normal, and task-related brain connectivity strengthened. The authors say the hybrid system may overcome the limits of conventional therapy and single-modality BCIs.

Austrian company g.tec medical engineering GmbH has registered a brain-computer interface rehabilitation trial in Parkinson's disease on ClinicalTrials.gov as NCT06690931, first posted on November 15, 2024 and marked completed as of the entry's September 3, 2026 update. It evaluates recoveriX PRO, which pairs motor imagination with functional electrical stimulation (FES) and virtual reality feedback, the user wearing an EEG cap whose recorded neural activity drives the feedback devices, and it asks whether the therapy significantly improves motor function, whether it outperforms standard treatment, and whether it is equally safe. The BCI group trains six times a week for four weeks, 24 sessions in all, while the control group gets the same schedule of FES and VR without EEG monitoring; no results are posted in the registry entry.