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2024-09-30 00:00 United States Clinical Results & Follow-up Translated from EN

Synchron Reports 12-Month COMMAND Results in Six U.S. Participants

入组10 例严重不良事件0 例随访24 个月
Summary Synchron reported 12-month results from the U.S. COMMAND early feasibility study in six people with severe chronic bilateral upper-limb paralysis. All participants met the primary safety endpoint of no device-related serious adverse event causing death or permanent increased disability, and motor-intent signals were converted into digital actions throughout the study. The disclosure was not a two-year pivotal-trial report.
Why it matters COMMAND provides a full year of U.S. human safety and signal-use data for an endovascular BCI, but a six-person feasibility cohort cannot substitute for a pivotal trial.
BCIwiki (bciwiki.com) — Synchron reported 12-month results from the U.S. COMMAND study on September 30, 2024. COMMAND was an FDA investigational device exemption early feasibility study that implanted Stentrode devices in six people with severe chronic bilateral upper-limb paralysis at three U.S. clinical sites.

Synchron said all six participants met the primary safety endpoint, with no device-related serious adverse event causing death or permanently increased disability during the first year. The company also reported no serious brain- or vascular-related adverse events. All devices were deployed at the intended target with motor-cortex coverage, and median deployment time was 20 minutes.

Motor-intent signals were consistently converted into digital actions on computers. The results were presented at the 2024 Congress of Neurological Surgeons. The public disclosure did not contain two-year follow-up and did not describe a completed pivotal trial. A six-person cohort also leaves long-term durability and broader-population risk unanswered.

Compiled by BCIwiki from public sources

Synchron timeline

2026-09 Carnegie Mellon Team Strips ECG Noise From Stentrode, Keeps Motor Signals 2026-07 Multimodal Imaging Workflow for Intraprocedural Targeting of Endovascular Stentrode Deployment 2025-11 Synchron Raises $200 Million Series D, Bringing Total Funding to $345 Million All entries →
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