Endovascular EEG recorded approximately 3.7 times the power of concurrent scalp EEG in 5 patients undergoing an intracarotid amobarbital injection, known as the Wada test, and the nearest endovascular-scalp electrode pairs showed consistently higher coupling in every participant, a mean difference of 4.9 percentage points ranging from 1.8% to 7.6% across individuals and most pronounced at separations under 30 mm. Endovascular EEG has emerged as a brain monitoring technique that balances signal fidelity against invasiveness, the authors write, matching subdural recordings in bandwidth and signal-to-noise ratio in animal studies, but its signal properties have been sparsely quantified in people. All signals were preprocessed with artifact rejection and independent component analysis, then assessed with power spectral density, imaginary coherence, phase-locking value and amplitude envelope correlation.
Why it matters
The case for endovascular electrodes has rested largely on animal work showing they approach subdural quality without a craniotomy, which leaves the human operating range unspecified. Measuring power and scalp coupling directly in patients converts that claim into numbers a device team can design against. The cohort is 5 patients recorded during a Wada test, so the setting is diagnostic rather than a working interface.