Wuhan Union Hospital Registers 1,000-Patient Cohort on Non-Invasive BCI for Stroke
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, in Wuhan, central China, is sponsoring a multicenter cohort study that aims to enroll 1,000 stroke patients. The treatment arm receives closed-loop rehabilitation combining a brain-computer interface with functional electrical stimulation, and the control arm receives conventional training; the primary endpoint is change in upper- and lower-limb FMA scores two weeks after enrollment. Registered with the Chinese Clinical Trial Registry as ChiCTR2600130037 on August 13, 2026, the study plans first enrollment on September 1, 2026 and has not yet begun recruiting. It will include patients aged 18 to 80 with ischemic or hemorrhagic stroke confirmed by MRI or CT, motor impairment of one upper and/or lower limb, and an NIHSS motor score of 1 for the affected limb. The registry lists it as an observational cohort study, phase 4, self-funded.
Why it matters
Closed-loop BCI plus functional electrical stimulation has been tested mostly in small studies; this one targets 1,000 patients, 500 per arm, an unusually large cohort for BCI stroke rehabilitation in China. The primary endpoint stops at 2 weeks while secondary endpoints run to 12 weeks, suggesting the team wants early motor gains first, then mid-term functional outcomes.