ClinicalTrials.gov

KK Women's and Children's Hospital in Singapore has registered a clinical trial of brain-computer interface neurofeedback training (BCI-NFT) for children and adolescents aged 7 to 21 with acquired brain injury from causes including traumatic brain injury, stroke, encephalitis, brain tumors and epilepsy. The intervention group will complete 12 sessions of about 60 minutes each over 10 weeks, wearing a wireless EEG headband while interacting with neurofeedback computer games; the control group receives standard care first and then crosses over to training. A cohort of peers with no history of brain injury will provide normative EEG data. The trial plans to enroll 70 participants, with primary endpoint results expected in February 2028.

Shanghai-based StairMed has taken its wireless implantable brain-computer interface system into human evaluation for people with speech impairments. The prospective, single-arm trial (NCT07647315) actually began on September 1, 2026, is now recruiting, and plans to enroll 4 participants. Subjects will undergo surgical implantation and brain-control training, followed by an expected 12 months of follow-up recording adverse events, serious adverse events and device deficiencies, along with efficacy data on brain-controlled interaction and communication. Primary completion is expected on August 30, 2028, and the study as a whole on December 30, 2028. The registry record does not disclose the implant site, decoding method or detailed eligibility criteria, and no interim results have been posted, so conclusions on safety and efficacy will have to wait for follow-up data.

A multicenter trial has begun in China to test closed-loop brain-computer interface neuromodulation for treatment-resistant depression, run jointly by the Shanghai Mental Health Center and two Beijing hospitals, Anding Hospital and Xuanwu Hospital. The study will compare closed-loop deep brain stimulation and transcutaneous auricular vagus nerve stimulation against sham stimulation, enrolling patients who have responded inadequately to standard antidepressant treatment. It uses a patient-preference design with randomized assignment within each intervention group.

National University Hospital in Singapore has registered a clinical trial (NCT07784920) evaluating Lifescapes, an EEG-based brain-computer interface, for hand motor recovery after stroke. The 32-participant study, not yet recruiting, will compare Lifescapes therapy delivered with reduced therapist supervision against conventional rehabilitation and assess whether it is operationally feasible in the local clinical setting. Lifescapes combines motor imagery practice, biofeedback, neuromuscular electrical stimulation and robotic assistance for stroke patients with severe hand paralysis; an earlier trial in 40 patients showed improvement in motor function.

BCIFlex Medical Technology has begun a clinical trial in China evaluating the safety and efficacy of an implantable wireless brain-computer interface in patients left tetraplegic by spinal cord injury. The trial is registered on ClinicalTrials.gov as NCT07784088 and is recruiting. The sponsor is a Chinese device maker headquartered in the Haidian district of Beijing with an office in Shanghai, working on invasive ultra-thin flexible electrodes; its products include digital EEG systems and stereo-EEG depth electrodes.

A new clinical trial at Brazil's Santos Dumont Institute will test whether brain-computer interface (BCI)-guided functional electrical stimulation (FES) can improve muscle activation and gait in people with spinal cord injury. The institute is a well-known Brazilian center for neurorehabilitation research. Registered on ClinicalTrials.gov as NCT07768930 and first posted on August 17, 2026, the study is active but not yet recruiting. The intervention involves ankle dorsiflexion rehabilitation: patients wear an EEG cap, the system detects motor-imagery-related brain signals in real time, and when an intention is detected, it triggers FES to stimulate the tibialis anterior muscle to assist ankle dorsiflexion. Primary outcomes are improvements in muscle activation patterns and gait kinematics. The trial is at an early stage, with enrollment details not yet disclosed.

A completed RCT compared BCI-controlled versus conventional exoskeleton gait training in stroke patients, training 2 times a week for 4 weeks.

The University of Aveiro in Portugal has registered a study (NCT07732868) testing a brain-machine interface protocol that pairs virtual reality with sensory feedback, visual, auditory and tactile, and/or an exoskeleton in people with spinal cord injury. Participants attend 12 monitored sessions, one a week, each lasting roughly one to two hours, moving a virtual avatar through motor imagery while non-invasive EEG records brain activity. The study focuses on changes in brain activity that track clinical improvement and on how information moves between brain regions, and it collects age, sex, injury level and type, time since injury, functional grade and neuropathic pain; it is at the registration stage with no results yet.

Ecole Polytechnique Fédérale de Lausanne (EPFL) has launched a clinical study evaluating the preliminary safety and effectiveness of a cortical recording device (ECoG) combined with lumbar targeted epidural electrical stimulation (EES) to restore voluntary lower-limb motor function in participants with chronic spinal cord injury and mobility impairment. The study aims to establish a direct bridge between motor intention and the spinal cord below the lesion, potentially improving or restoring voluntary leg control and promoting neurological recovery when combined with neurorehabilitation.

Hospices Civils de Lyon has registered a clinical study in France to decode motor imagery from non-invasive brain recordings as a prerequisite for innovative motor rehabilitation therapies. Combining MRI, MEG, and EEG, the study will design a subject-specific neurophysiological model, noting that standard BCI approaches neglect transient features such as beta bursts. The approach will first be validated in healthy subjects, then assessed for feasibility in stroke patients.

The VA Office of Research and Development is advancing a high-performance implanted brain-computer interface (BCI) to improve independence for Veterans and others with tetraplegia or inability to speak due to ALS, spinal cord injury, or stroke. The project enhances deep learning decoders and multi-state gesture decoding, deployed on a battery-powered mobile BCI device for independent home use of computers and touch-enabled devices. Accuracy and usability will be evaluated in participants already enrolled in the BrainGate investigational clinical trial.

The University of Texas at Austin has registered a study on ClinicalTrials.gov to explore whether an EEG-based brain-computer interface (BCI) decoding the P300 event-related potential in real time, combined with non-invasive interventions such as mindfulness relaxation or transcranial electrical stimulation, can enhance attention and memory neural markers—proxies for cognitive reserve—in healthy older adults and those with mild cognitive impairment (MCI). The trial is recruiting and aims to test whether targeted modulation of attention-related brain activity can support cognitive reserve.

NeuroXess registered a prospective, multicenter, single-arm trial (NCT07720882) enrolling people with tetraplegia caused by spinal cord injury to evaluate the safety and clinical efficacy of an implantable BCI system for compensatory hand movement and upper-limb functional replacement. The study is at the registration stage with no results yet.

Grenoble University Hospital has registered a clinical study (NCT07698496) assessing the feasibility and effectiveness of a chronic brain-computer interface for speech rehabilitation in people with locked-in syndrome (LIS), where non-invasive communication carries high cognitive load and existing invasive speech BCIs still rely on percutaneous connectors with infection risk. Using an intracranial epidural BCI paired with a speech synthesizer, the SpeechBCI protocol will test two complementary approaches in the same subject — a speech BCI (primary objective, the BCI_PAROLE device) and a cursor BCI (secondary), both running on the WIMAGINE intracranial epidural system. The trial is in the registration stage and has no clinical results yet.

Johns Hopkins University has launched the INTENT clinical trial to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different brain areas, enabling adults with disabling paralysis to control assistive devices and receive feedback. The trial is now recruiting participants with conditions including tetraplegia, ALS, brain stem stroke, and spinal cord injury. Johns Hopkins is a leading U.S. research university whose medical school is renowned in neuroscience. The trial was first posted on ClinicalTrials.gov on April 13, 2026, and is currently recruiting.

Neuracle Medical Technology (Shanghai) Co., Ltd. ran a clinical trial in China evaluating the safety and efficacy of its implantable wireless brain-computer interface, NEO, in patients with tetraplegia caused by spinal cord injury. The trial is registered on ClinicalTrials.gov as NCT06990412 and is listed as completed; its stated primary purpose was to provide the basis for product registration. NEO is designed to let patients control external devices with brain signals.

Austrian company g.tec medical engineering GmbH has registered a brain-computer interface rehabilitation trial in Parkinson's disease on ClinicalTrials.gov as NCT06690931, first posted on November 15, 2024 and marked completed as of the entry's September 3, 2026 update. It evaluates recoveriX PRO, which pairs motor imagination with functional electrical stimulation (FES) and virtual reality feedback, the user wearing an EEG cap whose recorded neural activity drives the feedback devices, and it asks whether the therapy significantly improves motor function, whether it outperforms standard treatment, and whether it is equally safe. The BCI group trains six times a week for four weeks, 24 sessions in all, while the control group gets the same schedule of FES and VR without EEG monitoring; no results are posted in the registry entry.

The University of Miami has opened a clinical trial testing whether a brain-computer interface can decode upper-limb motor intention from EEG or ECoG and use it both to trigger epidural spinal cord stimulation (ESCS) and to control assistive devices in people with spinal cord injury. The study was first posted on August 1, 2024, and is recruiting.

The University of Miami is recruiting participants with incomplete spinal cord injury for a walking rehabilitation trial combining a brain-computer interface with transcutaneous spinal cord stimulation. The trial is registered on ClinicalTrials.gov as NCT06406855 and is currently recruiting.

A randomized clinical trial called BCI-REHAB compared an at-home brain-computer interface (BCI) therapy system with a home exercise program for upper-extremity rehabilitation in chronic stroke survivors. The trial, conducted in the United States, was first posted on July 28, 2023, last updated on August 12, 2026, and has a status of completed. The study used Neurolutions' IpsiHand Upper Extremity Rehabilitation System, which reads motor intentions via scalp electrodes and drives an exoskeleton hand device to facilitate repetitive hand movement training. The trial aimed to evaluate the efficacy of BCI-based therapy versus standard exercise therapy and assess the potential for meaningful motor improvement in a home setting. The trial covered conditions including stroke, hemiparesis, spasticity as a sequela of stroke, and chronic stroke survivors with a plegic hand, but results have not yet been published.

The University of Texas at Austin has registered a study on ClinicalTrials.gov, NCT05907343, testing whether non-invasive stimulation can strengthen cognitive control in older adults, enrolling both people with cognitive impairment and people without it. It asks whether theta burst stimulation, a form of transcranial magnetic stimulation, can restore a range of cognitive functions, and whether delivering it in closed loop, timed to ongoing brain activity rather than on a fixed schedule, changes the result.

The VA Office of Research and Development is conducting a clinical trial to characterize proprioceptive sensations in the missing limb of upper limb amputees using nerve stimulation and to develop advanced controllers for moving a prosthesis. The trial uses Functional Electrical Stimulation (FES), applying small electric currents to the nerves, and tests different stimulation placements. The trial is registered as NCT04947462 and is currently recruiting.

Vanderbilt University Medical Center has developed a method that uses post-operative CT scans and image processing to determine the physical relationship between cochlear implant electrodes and the neural interface, allowing sub-optimally positioned electrodes to be switched off for a customized map. Cochlear implants are surgically implanted devices that restore hearing by electrically stimulating the auditory nerve, and their programming has traditionally ignored where the electrodes actually sit. The trial tested whether this individualized image-guided programming improves hearing and speech outcomes in pediatric recipients, with hearing measures collected at baseline, 12 months and 24 months; it has been completed, but results have not been posted.

Johns Hopkins University is conducting an early feasibility study to evaluate the safety and efficacy of the Bidirectional Cortical Neuroprosthetic System (BiCNS). The system comprises NeuroPort Microelectrode Array Systems, NeuroPort Electrodes (Sputtered Iridium Oxide Film), Patient Pedestals, the NeuroPort BioPotential Signal Processing System, and the CereStim C96 Programmable Stimulator. The trial enrolls patients with tetraplegia and quadriplegia and is currently recruiting.