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Invasive BCI

123 entries

Invasive brain-computer interfaces record neural signals directly from electrode arrays implanted in the cortex, achieving the highest signal resolution and decoding accuracy of any BCI approach. This topic tracks clinical trials, device engineering, and regulatory milestones across leading players including Neuralink, Blackrock Neurotech, Paradromics, and Precision Neuroscience.

July 2026
07-06 · INBRAIN Neuroelectronics United StatesSpain Industry News Progress & Expansion

INBRAIN and Microsoft Team Up on AI for Neurology and BCI

Barcelona-based INBRAIN Neuroelectronics said it will work with Microsoft on AI for neurology and brain-computer interfaces, combining INBRAIN's neuroscience, bioelectronics and AI work with Microsoft's cloud and AI infrastructure. INBRAIN's graphene-based neural interface is being developed as an adjunctive therapy for Parkinson's disease; it received FDA breakthrough device designation in 2023 and entered its first-in-human study in the fall of 2025.
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07-03 · Tsinghua University China Papers Foundations & Methods

Beihang and Tsinghua Team Fuses EEG, Video and Motion to Flag VR Cybersickness

Researchers at Beihang University and Tsinghua University in Beijing built a multimodal contrastive learning framework that pairs EEG with synchronized video and motion data to detect cybersickness in virtual reality, representing the EEG as a connectivity graph and using an attention-based encoder to map the video and motion streams onto the same structure. Fusing all three signals separated cybersick from non-cybersick states more cleanly than any single modality or pair, and the model automatically pruned prefrontal connections unrelated to cybersickness. The setup used mBrainTrain's Smarting PRO 32-channel wireless EEG system and a Pico 4 Ultra headset, with 29 healthy adults navigating a VR scene under their own control.
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07-03 · Shanghai Jiao Tong University +3 more China Papers Foundations & Methods

Study Involving Hangzhou Dianzi University Achieves 1024-Channel Recording in Pig Cortex

A collaborative study involving authors from Hangzhou Dianzi University and other institutions developed a three-dimensional helical stretchable neural probe and achieved 1024-channel signal acquisition in the pig cerebral cortex. The researchers also report single-unit recordings with long-term stability in the mouse deep brain, while flexible planar microelectrode arrays recorded subcutaneous EMG signals in mice. The probe is fabricated using planar microfabrication followed by thermally driven helical shaping, expanding wiring space and accommodating tissue motion. Mechanical simulations and cyclic stretching tests examined strain mitigation and electrochemical stability, respectively. These device and animal results do not establish long-term performance in humans.
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07-02 · Johns Hopkins University +3 more United StatesNetherlands Papers Foundations & Methods

Preprint: MRI Grey Matter Loss May Predict Who Can Control an ECoG BCI in ALS

A preprint from the Utrecht-BCI Lab at the UMC Utrecht Brain Center in the Netherlands, the invasive-BCI group led by Nick Ramsey, asks why some people with ALS control an implanted brain-computer interface (BCI) better than others. It found that preservation of grey matter in the motor cortex is associated with higher-quality brain signals, suggesting an MRI-based measure could help identify who is a suitable candidate for implantation. The preprint was posted to medRxiv on June 23, 2026 (DOI 10.64898/2026.06.23.26355654).
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June 2026
06-18 · OYMotion China Industry News Progress & Expansion

OYMotion and MicroPort NeuroScientific Partner on Endovascular BCI Rehab System

OYMotion and MicroPort NeuroScientific signed a strategic cooperation agreement on May 28, 2026 to jointly develop an interventional brain-computer interface rehabilitation system. The first product will be a multi-channel endovascular BCI that threads a signal-recording stent through the blood vessels to a target brain region, capturing intracranial electrical activity without opening the skull. MicroPort NeuroScientific will build the BCI system as a whole and OYMotion the limb side, with the pair targeting medical rehabilitation and human-machine interaction.
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06-17 · Neuracle China Policy & Regulation Regulatory Approval

Neuracle Registers UDI for Implantable EEG Electrode Kit

Neuracle Medical Technology (Shanghai) Co., Ltd. registered an Implantable EEG Electrode Kit in the NMPA Medical Device Unique Identification database. The model is K1014-15, and the registration certificate number is 国械注准20263120536. The listed kit includes a cortical electrode, a blank electrode, and surgical and fixation components. It is both a product with its own registration certificate and a component of an implantable brain-computer interface hand motor function compensation system. The system also includes an implant, an EEG transceiver, a pneumatic glove device, and software. This entry identifies the product and its composition; it does not establish the complete system's registration status or clinical performance.
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06-17 · Neuracle China Policy & Regulation Regulatory Approval

Neuracle Registers UDI for NEO-M Pro Hand Motor Function Compensation System

Neuracle Medical Technology (Shanghai) Co., Ltd. registered the Implantable Brain-Computer Interface Hand Motor Function Compensation System in the NMPA Medical Device Unique Identification database. Its model is NEO-M Pro, and its registration certificate number is 国械注准20263120537. The description lists a BCI implant, an implantable EEG electrode kit, a disposable surgical tool kit, an EEG signal transceiver, a pneumatic glove device, and three software products, each with release version 1.0. The entry provides product identification and composition information; UDI registration itself should not be interpreted as validation of clinical efficacy or safety.
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06-17 · Neuracle China Policy & Regulation Regulatory Approval

Neuracle Registers UDI for K1014-25 Implantable EEG Electrode Kit

Neuracle Medical Technology (Shanghai) Co., Ltd. registered the K1014-25 Implantable EEG Electrode Kit in the NMPA Medical Device Unique Identification database. Its registration certificate number is 国械注准20263120536. According to the company's registered description, the kit includes a cortical electrode, a blank electrode, and associated tools and fixation components. It is both a product with its own registration certificate and a component of an implantable brain-computer interface hand motor function compensation system. The entry also lists the system's EEG transceiver, pneumatic glove device, and software. It identifies the kit and its relationship to the system; UDI registration itself does not validate clinical efficacy or safety.
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06-17 · Neuracle China Policy & Regulation Regulatory Approval

Neuracle Registers UDI for K1014-35 Implantable EEG Electrode Kit

Neuracle Medical Technology (Shanghai) Co., Ltd. registered the K1014-35 Implantable EEG Electrode Kit in the NMPA Medical Device Unique Identification database. Its registration certificate number is 国械注准20263120536. The company's description lists a cortical electrode, a blank electrode, and associated tools and fixation components. It describes the kit as both a product with its own registration certificate and a component of an implantable brain-computer interface hand motor function compensation system. The notes also list an EEG transceiver, a pneumatic glove device, and software within that system. The kit's UDI entry alone does not confirm the complete system's registration status or clinical performance.
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06-17 · Neuracle China Policy & Regulation Regulatory Approval

Neuracle Registers UDI for NEO-M Hand Motor Function Compensation System

Neuracle registered the NEO-M Implantable Brain-Computer Interface Hand Motor Function Compensation System in the NMPA Medical Device Unique Identification database. Its registration certificate number is 国械注准20263120537. According to the company's description, the system includes a BCI implant, an implantable EEG electrode kit, a disposable surgical tool kit, an EEG signal transceiver, a pneumatic glove device, and EEG decoding, medical testing, and clinical management software. All three software products have release version 1.0. The entry identifies the product and its components; UDI registration itself does not validate clinical efficacy or safety.
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06-12 · NeuroXess China Industry News Progress & Expansion

NeuroXess Says Two Paralyzed Patients Played Brain-Controlled Chess 800 km Apart

NeuroXess said two people with high-level paralysis played chess against each other across about 800 kilometers, between Shanghai and Nanchang in eastern China, using its "Triple-Full" (三全) brain-computer interface: one selected and placed pieces on a virtual board by thought, with the commands relayed in real time to a robot stand-in that moved the pieces at the other end, where the second participant gripped physical pieces through a brain-controlled exoskeleton glove. The company said the first participant was implanted at Huashan Hospital, Fudan University, in October 2025, moved a cursor by thought on the fifth day after surgery and reached 5.2 bits per second after 17 days of training, while the second was implanted at the First Affiliated Hospital of Nanchang University in December 2025 and was eating, drinking and writing with a brain-controlled exoskeleton one month after surgery. The outcomes come from the vendor's own account and have not been validated in peer-reviewed publication.
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06-11 · Neuracle China Funding Public Markets

China's Neuracle Files for Shanghai IPO, Seeking RMB 2.5 Billion

The Shanghai Stock Exchange accepted an IPO application from Neuracle, which is seeking RMB 2.5 billion for BCI product development, industrialization and working capital. The filing shows an established non-invasive neurophysiology equipment business alongside invasive products that still require clinical, regulatory and commercialization spending. Acceptance starts the review process and is not approval to list.
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May 2026
05-28 China Clinical Launch & Registration

ChiCTR Registers Trial of Motor Imagery BCI for Lower-Limb Stroke Rehab

The Chinese Clinical Trial Registry (ChiCTR) has logged a study of how brain-computer interface training built on a motor imagery paradigm affects lower-limb motor function in stroke patients. Registered on May 28, 2026 as ChiCTR2600125562, the trial is recruiting; design, sample size and sponsor are absent from the record carried by the WHO International Clinical Trials Registry Platform (ICTRP) and must be read from the original ChiCTR entry.
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05-22 China Clinical Launch & Registration

China Registers Trial of Multimodal BCI for Early Alzheimer's Screening

A Chinese team has registered a clinical trial of a multimodal brain-computer interface system for intelligent diagnosis and treatment, aimed at early screening and non-invasive modulation of Alzheimer's disease. The entry, ChiCTR2600125240, was filed with the Chinese Clinical Trial Registry on May 22, 2026 and is carried by the WHO International Clinical Trials Registry Platform; recruitment has not begun.
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05-19 · University of Bath +2 more ChinaUnited Kingdom Papers Foundations & Methods

sEEG Study Finds Motor Imagery Activity Shifts by Task Stage and Frequency Band

Intracranial recordings from ten epilepsy patients show that neural activity during cued limb motor imagery changes with the phase of the task: low-frequency (8-30 Hz) activity was mostly suppressed during preparation and switched to activation once imagery began, while high-frequency (60-115 Hz) responses were stronger, more widely distributed, and at some contacts followed an activation-then-suppression sequence. The stereoelectroencephalography (sEEG) data indicate that responses are not uniform but shift with task stage and brain region, which the authors tie to stage-aware feature design for BCIs and to neurorehabilitation.
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05-19 China Clinical Launch & Registration

Chinese Trial Pairs Tactile-Feedback BCI With Motor Imagery for Stroke Arm Recovery

A trial combining tactile-feedback brain-computer interface training with motor imagery for upper-limb rehabilitation after stroke is recruiting in China. Registered with the Chinese Clinical Trial Registry as ChiCTR2600124911 on May 19, 2026 and carried by the WHO International Clinical Trials Registry Platform, the trial record is available through the WHO International Clinical Trials Registry Platform.
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April 2026
04-20 · The First Affiliated Hospital of Jinan University China Clinical Launch & Registration

Dual-Task BCI and VR Enter Trial for Shoulder Recovery After Rotator Cuff Repair

A trial of a dual-task brain-computer interface (BCI) combining motor-intention detection with virtual reality training is recruiting patients to measure how it affects shoulder function after rotator cuff repair surgery, following its registration with the Chinese Clinical Trial Registry (ChiCTR) on April 20, 2026. The record has been reposted by the WHO International Clinical Trials Registry Platform (ICTRP).
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04-13 · Blackrock Neurotech +3 more United States Clinical Launch & Registration

Johns Hopkins launches INTENT trial of implant that reads and stimulates brain to help paralyzed control devices

Johns Hopkins University has launched the INTENT clinical trial to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different brain areas, enabling adults with disabling paralysis to control assistive devices and receive feedback. The trial is now recruiting participants with conditions including tetraplegia, ALS, brain stem stroke, and spinal cord injury. Johns Hopkins is a leading U.S. research university whose medical school is renowned in neuroscience. The trial was first posted on ClinicalTrials.gov on April 13, 2026, and is currently recruiting.
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March 2026
03-27 · Shandong Public Health Clinical Center China Clinical Results & Follow-up

Combined BCI and Gait-Robot Training Beats Either Alone in Stroke Trial

A randomized controlled trial in 120 patients with post-stroke hemiplegia found that pairing brain-computer interface (BCI) rehabilitation training with a gait robot accelerated lower-limb recovery and improved muscle activation patterns more than either intervention on its own. After eight weeks, BCI training, gait-robot training and the combination all improved lower-limb motor function, muscle activity and gait compared with routine training, but the combined group showed the largest increases in integrated electromyography of the tibialis anterior and gastrocnemius, along with a greater gain in step frequency and a greater reduction in step width.
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January 2026
December 2025
12-05 · Huazhong University of Science and Technology +2 more China Policy & Regulation Progress & Expansion

China Bills a Brain Implant Under a State-Set Price for the First Time

Tongji Hospital in Wuhan implanted a 64-channel high-throughput flexible electrode array made by Wuhan Neuracom into a 31-year-old man paralysed by a spinal cord injury on 26 November 2025. The procedure was charged under the country's first BCI medical service price schedule, issued by Hubei's healthcare security bureau in March 2025, which sets implantation at 6,552 yuan. China's National Healthcare Security Administration calls it the first BCI operation in the country carried out under a state-set price. This patient's costs were covered by research funding.
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May 2025
05-25 · Neuracle China Clinical Launch & Registration

Neuracle Completes Trial of Its Wireless NEO Implant in Tetraplegia

Neuracle Medical Technology (Shanghai) Co., Ltd. ran a clinical trial in China evaluating the safety and efficacy of its implantable wireless brain-computer interface, NEO, in patients with tetraplegia caused by spinal cord injury. The trial is registered on ClinicalTrials.gov as NCT06990412 and is listed as completed; its stated primary purpose was to provide the basis for product registration. NEO is designed to let patients control external devices with brain signals.
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05-12 · Department of Economy and Information Technology of Sichuan Province China Policy & Regulation Industrial Planning

Sichuan Targets 3,000 Brain Implant Ops a Year

Eight Sichuan provincial departments in southwestern China led by the Department of Economy and Information Technology issued the Action Plan for Breakthroughs in the Brain-Computer Interface and Human-Machine Interaction Industry in Sichuan (2025-2030) on May 12, 2025. The plan is unusual in making surgical volume a headline metric, targeting 3,000 invasive BCI procedures a year by 2030, along with services for more than 100,000 patients a year with neurodegenerative disease, psychiatric conditions and drug or digital addiction, and rehabilitation device use exceeding 20,000 sessions a year. By 2027 it aims to complete development and medical device registration of three invasive and five non-invasive products, carry out the province's first invasive BCI operation, serve more than 50,000 patients a year, and cultivate 10 chain-leading firms, 100 specialised SMEs and 200 innovative smaller enterprises. Chengdu, Mianyang, Deyang and Nanchong are named as host cities.
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August 2024
08-21 · Neuralink United States Clinical Safety & Termination

Neuralink Details Thread Retraction and Surgical Changes in PRIME Study

Neuralink said thread retraction in its first PRIME participant temporarily reduced BCI performance before the threads stabilized and performance recovered. For the second implant, the team reduced brain motion during surgery and narrowed the gap between the implant and the brain surface. The company reported no thread retraction in the second participant at the time, but it did not publish channel-attrition rates or a formal interim safety report.
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08-01 · University of Miami United States Clinical Launch & Registration

University of Miami Launches Trial Using BCI to Trigger Spinal Cord Stimulation

The University of Miami has opened a clinical trial testing whether a brain-computer interface can decode upper-limb motor intention from EEG or ECoG and use it both to trigger epidural spinal cord stimulation (ESCS) and to control assistive devices in people with spinal cord injury. The study was first posted on August 1, 2024, and is recruiting.
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May 2024
February 2024
02-29 · Neuracle China Clinical Launch & Registration

China's Neuracle Registers 96-Patient Trial of Closed-Loop Epilepsy Implant

Chinese registry ChiCTR2400081380 describes a 96-patient trial of an implantable closed-loop recording and stimulation system for focal drug-resistant epilepsy in people aged 6 to 70. All participants are to receive the implant and then be randomized one month later to active or sham stimulation, 48 per group. The registry provides no evidence that enrollment had passed 50%.
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